Experimental models of mucosal inflammation

Cover of: Experimental models of mucosal inflammation |

Published by CRC Press in Boca Raton .

Written in English

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  • Gastroenteritis -- Animal models.,
  • Gastrointestinal mucosa -- Inflammation -- Animal models.,
  • Mucous Membrane -- physiopathology.,
  • Inflammation -- physiopathology.,
  • Disease Models, Animal.,
  • Inflammation -- physiopathology.

Edition Notes

Includes bibliographical references and index.

Book details

Statementedited by Timothy S. Gaginella.
SeriesPharmacology and toxicology, Pharmacology & toxicology (Boca Raton, Fla.)
LC ClassificationsRC840.G3 E96 1996
The Physical Object
Pagination139 p. :
Number of Pages139
ID Numbers
Open LibraryOL1279557M
ISBN 100849378168
LC Control Number95011357

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Experimental Models of Mucosal Inflammation (Handbooks in Pharmacology and Toxicology) 1st Edition by Timothy S. Gaginella (Author)Author: Timothy S. Gaginella.

Written by active researchers in the field, this unique book provides a detailed review of esophageal, gastroduodenal ileal, and colonic models of mucosal inflammation and ulceration.

Animal Models of Mucosal Inflammation not only presents up-to-date techniques and models but also provides the latest data on the mechanistic approach to treatment and. Experimental Models of Mucosal Inflammation - CRC Press Book Written by active researchers in the field, this unique book provides a detailed review of esophageal, gastroduodenal ileal, and colonic models of mucosal inflammation and ulceration.

Experimental Models of Mucosal Inflammation Article Literature Review in Advances in Experimental Medicine and Biology February with 7. Final Common Pathways of Experimental models of mucosal inflammation book Mucosal Inflammation.

Although experimental models of mucosal inflammation arise from a myriad of causes, they are thought to be characterized by a Th1/Th2 paradigm in that they usually resolve into a Th1 or a Th2 final common pathway of responsiveness (Strober et al., ).

The Th1 pathway is predominant, since most models are characterized by excessive IFN-γ responses Author: Monica Boirivant. Experimental models of inflammatory bowel diseases have provided valuable insights into the complex mechanisms operative in the development and pathogenesis of these diseases.

This review describes widely used models and how they help us understand the immunology of intestinal by: The Immunology of Mucosal Models of Inflammation. What emerges is that murine models of mucosal inflammation have given us a road map that allows us to begin to define the immunology of the IBDs in all its complexity and to find unexpected ways to treat these diseases.

Experimental evidence for the existence of the equilibrium phase of Cited by: The immunology of mucosal models of inflammation Article Literature Review in Annual Review of Immunology 20(1) February with Reads How we measure 'reads'. Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular.

Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing pain includes comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions.

Models of Mucosal Inflamation: Pharmacological Considerations. Rabbit Model of Reflux Esophagitis. Isolated Gastric Mucosal Cells and Glands as Models for Mechanistic and Pharmacologic Studies of Acute Injury.

Animal Models of Duodenal Ulceration. Models of Ileitis. Animal Models of Colitis. In Vitro Models of Epithelial Pathophysiology. Index. Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease.

This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach. Elson CO, Sartor RB, Tennyson GS, Riddell RH () Experimental models of inflammatory bowel disease.

Gastroenterology – PubMed CrossRef Google Scholar Emmrich J, Seyfarth M, Fleig W, Emmrich F () Treatment of inflammatory bowel disease with anti-CD4 monoclonal by: 2.

Experimental Models of Inflammatory Bowel Diseases Patricia Kiesler, Ivan J. Fuss, and Warren Strober Mucosal Immunity Section, Laboratory of Host Defenses, National Institutes of Health, Bethesda, Maryland SUMMARY Experimental models of inflammatory bowel diseases have provided valuable insights into the complex mechanisms.

Experimental model of oral ulcer in mice: Comparing wound healing in three immunologically distinct animal lines Paulo Goberlânio de Barros Silva, 1 Érian Bezerra Belo de Codes, 1 Milena Oliveira Freitas, 1 Joyce Ohana de Lima Martins, 1 Ana Paula Negreiros Nunes Alves, 2 and Fabrício Bitu Sousa 1, 2.

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders.

Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including 5/5(1).

alleviates mucosal inflammation in experimental models Anna Pérez-Bosque and Miquel Moretó Grup de Fisiologia i Nutrició Experimental, Departament de Fisiologia, Facultat de Farmàcia Institut de Recerca en Nutrició i Seguretat Alimentària, Universitat de Barcelona, Spain Abstract.

The intestinal and bronchoalveolar mucosae contribute to. The role of neutrophils during intestinal inflammation. Mucosal Immunol.

5 Rieder, F. et al. Intestinal proteomic analysis of a novel non-human primate model of experimental colitis reveals Cited by: 2. Figure 1. Composition of gastric mucus. condition. Mucus rapidly responds to pathological and physiological changes in the stomach. Moreover, mucus present in the stomach exhibits various actions such as maintaining lubrication of the mucosal surface, covering ingested foods to mix them, helping digestion, and protecting the surface epithelium from irritation by forming a thick Cited by: 5.

Inflammatory bowel disease (IBD) is a complex multifactorial disease of unknown etiology. Thus, dozens of different animal models of IBD have been developed in past decades.

Animal models of IBD are valuable and indispensable tools that provide a wide range of options for investigating involvement of various factors into the pathogenesis of IBD and to evaluate different Cited by:   Adrenomedullin (AM) is a novel hypotensive peptide that also exerts powerful anti-inflammatory effects.

We recently showed that AM significantly reduces the clinical severity of acetic acid-induced colitis, an experimental model of inflammatory bowel disease (IBD) in rats. In the present study, we examined the effect of AM in two alternative rat models of IBD. In one major area of study, Section scientists have made extensive use of experimental models to understand the complex cellular and molecular events governing mucosal inflammation.

This pathway of research has led to new insights into the effector and regulatory mechanisms at play during gastrointestinal inflammation and to the development of. Thirdly, that mucosal inflammation is the result of a polarized Th1/Th17 or Th2 T cell-mediated process, although in the majority of the models inflammation has of both innate and adaptive components.

This is a major organizing concept that has helped to target our therapeutic arsenal on specific immunological pathways. Furthermore, murine Cited by:   The exaggerated DSS-induced inflammation that we observed in SOD Tg mice was unexpected since SOD is known to protect tissues against inflammation-mediated injury.

The antiinflammatory properties of SOD, which relate to the enzyme's ability to eliminate superoxide, have been demonstrated in a variety of experimental models (11, 45).Cited by: Contamination, Infection and Inflammation Control in an Experimental Mucosal Cyst Model Using Athymic Nude Mice M.

Wang MSc (Dent) thesis, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, University of the Western Cape Various experimental cyst models have been developed in animals to study theAuthor: Meng Wang.

Inflammatory bowel diseases (IBDs) comprise primarily two disease manifestations, ulcerative colitis (UC) and Crohn’s disease (CD), each with distinctive clinical and pathological features. Environmental and clinical factors strongly affect the development and clinical outcomes of IBDs.

Among environmental factors, cigarette smoke (CS) is considered the most important risk Author: Giuseppe Lo Sasso, Walter K. Schlage, Blaine Phillips, Manuel h, Julia Hoeng.

Background Hypersensitivity or uncontrolled responses against dietary antigens can lead to inflammatory disorders like food allergy and current models reflect a variety of causes but do not reveal the detailed modulation of gut immunity in response to food antigens after breakdown in mucosal tolerance.

Objective To develop and characterize a murine model Cited by: Mucosal Immunology Seroreactivity to these flagellins is found in multiple experimental models of colitis in mice and in half of patients with Crohn's disease. PhD The overarching research objective of the Lund laboratory is to identify the key players that suppress or exacerbate mucosal inflammatory responses with the long-term goal of.

Pathology of the Gastrointestinal Tract PDF Author Elizabeth A. Montgomery MD Isbn File size MB Year Pages Language English File format PDF Category Free Medical Books,Gastroenterology,Pathology Download the Book Download Book Description: Biopsy Interpretation of the Gastrointestinal Tract Mucosa is your definitive bench.

Free Online Library: A novel diabetic murine model of Candida albicans-induced mucosal inflammation and proliferation.(Research Article, Report) by "Journal of Diabetes Research"; Health, general Health aspects Candidiasis Models Risk factors Complications and side effects Diabetes mellitus Inflammation Mucous membrane.

experimental models of enterocolitis have led to progress. Intestinal inflammation and experimental IBD can be induced by chemical or dietary factors or by microbial products.

Many animal models of IBD can be used to evaluate new anti-inflammatory drugs. These models, however, usually demonstrate acute, self-limiting by: This model involves an acute inflammatory response followed by impaired esophageal mucosal integrity, even in the absence of inflammation.

Thus this model can serve for evaluation of pathophysiological aspects of NERD and open new perspectives for therapeutic strategies for patients with this by: 4. Experimental Models of Intestinal Inflammation: New Insights into Mechanisms of Mucosal Homeostasis / Charles O. Elson Gastrointestinal Lymphoma / Andrew C.

Wotherspoon, Thomas T. MacDonald and Jo Spencer Peptic Ulcers and Gastritis / Steven J. Czinn, Martin J. Blaser and John G. Nedrud Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO the nlrp3 inflammasome.

miR was increased in intestinal biopsies from patients with active IBD and in preclinical models of intestinal inflammation. miR/y mice presented with exacerbated myeloid-driven experimental colitis with Cited by: The pathogenesis of mucosal inflammation in murine models of inflammatory bowel disease and Crohn disease.

Ann Intern Med –, Crossref | PubMed | ISI Google Scholar; 19 Wirtz S and Neurath MF. Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel by: The T cell transfer model of IBD is reproducible and easily manipulated and therefore provides an excellent system for the study of immunopathology and immune regulation in the intestine.

Key Words Colitis inflammatory bowel disease regulatory T cells mucosal immunology cell sortingCited by: The human gut relies on several cellular and molecular mechanisms to allow for an intact and dynamical intestinal barrier.

Normally, only small amounts of luminal content pass the mucosa, however, if the control is broken it can lead to enhanced passage, which might damage the mucosa, leading to pathological conditions, such as inflammatory bowel disease (IBD).Cited by: 8. The most interesting models are thus those that share not only clinical and pathological characteristics with IBD, but also early mucosal abnormalities.

From that point of view, the nonsteroidal anti-inflammatory drug (NSAID) enteropathy is probably one of the most interesting model for Crohn's disease (CD).Cited by: 5.

S. herba extract exerted an intestinal anti-inflammatory effect in both experimental models of colitis, as evidenced both histologically, since it facilitated the tissue recovery of the damaged colon, and biochemically as showed by the improvement of the different inflammatory markers evaluated, including myeloperoxidase activity, glutathione content, and Cited by: Free Online Library: Experimental Colitis Is Attenuated by Cardioprotective Diet Supplementation That Reduces Oxidative Stress, Inflammation, and Mucosal Damage.(Research Article) by "Oxidative Medicine and Cellular Longevity"; Biological sciences Arginine Dextran Dextrans Drinking water Gastrointestinal system Immune response Development and progression Diet.

This article is from Mucosal Immunology, volume ctThe increasing incidence of inflammatory bowel diseases (IBDs) in developing countries has. EXPERIENCE FROM EXPERIMENTAL MODELS OF COLITIS. The presence of intestinal bacteria is essential in several animal models of colitis.

These models exist on varied genetic backgrounds, including mice that are deficient in interleukin (IL), 10 T cell receptor alpha beta, 11 T cell receptor alpha, 12 and also CD3-epsilon transgenic mice 13 or HLA-B27 Cited by:   The polysaccharide microsphere delivered dexamethasone directly to the colon of TNBS experimental colitis avoiding upper absorption and showing synergistic effects on colitis.

81 Dexamethasone, studied also in solid lipid NPs with butyrate, resulted effective in counteract inflammatory activity in a human IBD whole-blood model. 82 However Cited by:

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